Bio-Identical Hormone Replacement Therapy



Declining hormone levels are a natural part of life for both men and women, especially after the age of 40.

MENOPAUSE is defined as the time in a woman’s life when they have gone 12 months without experiencing a menstrual cycle. Hormone levels, especially those of estrogen and progesterone, can then drop drastically and have a massive impact on whole-body health. Although the average age of a woman who qualifies as being menopausal is 51, this condition can still affect women who are in their 40s. Even if menopause has not occurred yet, most women start to experience perimenopause or the “menopause transition” in their 40s. While the intensity of menopausal symptoms can vary from one individual to the next, most women will experience hot flashes at some point during menopause. This condition, which is defined by sudden increases in body temperature, is the most common symptom of menopause by a wide margin. In fact, roughly 75 percent of menopausal women experience hot flashes. Unfortunately, menopause can lead to a wide range of SYMPTOMS and CONDITIONS that can threaten comprehensive wellness, including:

  • Hot flashes
  • Night sweats
  • Sleep issues, including insomnia
  • Vaginal dryness
  • Reduced sex drive
  • Increase in body fat
  • Dry skin
  • Reduced metabolic function
  • Mood swings and increased risk of depression
  • Issues with memory and concentrating
  • Reduced bone density and an increased risk of osteoporosis
  • Increased risk of cardiovascular disease

Men also have to contend with hormonal imbalance, ESPECIALLY AFTER THE AGE OF 40. This condition, which is sometimes referred to as ANDROPAUSE, revolves around the decreased production of one specific hormone: testosterone. The decreased production of testosterone is a form of late-onset hypogonadism. The drop in testosterone levels is more gradual than the drop in hormone levels that menopausal women experience; the average reduction works out to just over one percent each year after the age of 40. However, THESE LOW TESTOSTERONE LEVELS can still lead to a variety of symptoms and conditions that include:

  • Hot flashes
  • Reduced sex drive
  • Erectile dysfunction (ED)
  • Depressed mood and increased risk of depression
  • Increased body fat
  • Fatigue
  • Reduced muscle mass and strength
  • Enlarged male breast tissue (gynecomastia)
  • Increased risk of CARDIOVASCULAR DISEASE


HRT can be administered to men and women in a wide variety of options. Unfortunately, there are NEGATIVE ASPECTS for each of these options that have the potential to make HRT uncomfortable, painful or even less effective.

There are also a wide range of side effects that can result from the use of standard HRT, including bloating, nausea, headaches, mood swings, gastrointestinal (GI) issues and weight changes. Some researchers also believe that standard HRT using synthetic hormones can increase the risk of blood clots and even certain types of cancer.


Creams and gels have long been popular HRT methods, especially for hormones like progesterone and estrogen. One of the main issues with creams and gels is the inconvenience of these methods; they generally need to be administered on a daily basis. This can be a problem for people if they run out of medications, as a disruption in therapy can result in hormonal imbalance. They also do not absorb into the bloodstream immediately, because they need to be absorbed into the skin first.

For women, creams and gels can also lead to additional side effects like breast tenderness and vaginal bleeding. They can also be uncomfortable, and they can even transfer to other people if their skin comes in contact with the medication.


Pills and capsules are other delivery methods that need to be administered on a regular basis, so they can be just as inconvenient as creams and gels. They also carry the same risk for other people, or even pets, if they are ingested accidentally.

Like creams and gels, pills and capsules are not absorbed directly into the bloodstream. First, they must pass through the GI TRACT AND LIVER.


LIQUID INJECTIONS are the most widely used delivery method for testosterone in men. Testosterone injections only need to be administered every 7 days or so, and they go directly into the bloodstream. However, they carry the same risks associated with creams, gels, capsules and pills. Additionally, testosterone injections can lead to side effects as the injection site, including irritation, bleeding and pain.


Many women and men have turned to pellet therapy for their convenience and efficacy. After analyzing a person’s hormone levels, a highly trained practitioner can send a customized prescription to a compounding pharmacy. The compounding pharmacy can use this prescription to compound all-natural, plant- based hormones that mimic the hormones in that specific person’s body, which has the potential to reduce many of the side effects that can accompany synthetic hormones.

Once the customized hormone clusters have been compounded into a pellet that is roughly the size of a grain of rice, this practitioner can then insert this pellet under the skin. When working optimally, this pellet slowly releases the customized hormones into the bloodstream as needed for a couple months at a time.

Unfortunately, standard hormone pellets do not always work as intended. Some men and women complain of inconsistent or “rollercoaster” dosing that does not always release the hormones when they are needed most. In some cases, standard pellet insertions can also lead to discomfort, pain and extruding pellets at the insertion site.


The EvexiPEL Method was developed by Dr. Terri DeNeui, DNP, APRN, ACNP– BC, Founder and Chief Medical Officer of EVEXIAS Health Solutions, following 15 years of extensive research. Dr. DeNeui had found herself frustrated with the reactionary approach of traditional medicine and began to immerse herself in the preventative approach of integrative medicine. After hearing about some of the less favorable patient experiences with standard hormone pellets, she also wanted to develop a pellet insertion procedure that could offer a more comfortable and effective experience.

The EVEXIPEL Method utilizes patented pellet formations from FarmaKeio Outsourcing, an FDA-approved 503B outsourcing facility. These pellets have been expertly designed for precision and durability so that they can deliver consistent dosing as needed over time. To further enhance comfortability and efficacy at each procedure, EvexiPEL practitioners have been trained to insert pellets in a way that minimizes pain and trauma to the insertion site. This not only makes for a more pleasant experience both during and after each procedure, but it also helps to ensure that the pellets can function at an optimal level below the surface level of the skin with a reduced risk of pellet extrusions.

Still unsure as to whether or not Bio-Identical Hormone Replacement Therapy is right for you? Scan the QR code below to take a quick, simple, and free assessment.

EvexiPEL Bio-Identical Hormone Therapy Testimonials

Our incredible Co-Founder of EvexiPEL,
Dr. Terri DeNeui, speaks on hormones

Previous Next
Test Caption
Test Description goes like this
Scroll to Top